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KMID : 1161420110140040334
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Journal of Medicinal Food
2011 Volume.14 No. 4 p.334 ~ p.343
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A Combination of Green Tea Extract and l-Theanine Improves Memory and Attention in Subjects with Mild Cognitive Impairment: A Double-Blind Placebo-Controlled Study
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Park Sang-Ki
Jung In-Chul
Lee Won-Kyung
Lee Young-Sun
Park Hyoung-Kook
Go Hyo-Jin
Kim Ki-Seong
Lim Nam-Kyoo
Hong Jin-Tae
Ly Sun-Yung
Rho Seok-Seon
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Abstract
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A combination of green tea extract and l-theanine (LGNC-07) has been reported to have beneficial effects on cognition in animal studies. In this randomized, double-blind, placebo-controlled study, the effect of LGNC-07 on memory and attention in subjects with mild cognitive impairment (MCI) was investigated. Ninety-one MCI subjects whose Mini Mental State Examination-K (MMSE-K) scores were between 21 and 26 and who were in either stage 2 or 3 on the Global Deterioration Scale were enrolled in this study. The treatment group (13 men, 32 women; 57.58?±?9.45 years) took 1,680?mg of LGNC-07, and the placebo group (12 men, 34 women; 56.28?±?9.92 years) received an equivalent amount of maltodextrin and lactose for 16 weeks. Neuropsychological tests (Rey?Kim memory test and Stroop color?word test) and electroencephalography were conducted to evaluate the effect of LGNC-07 on memory and attention. Further analyses were stratified by baseline severity to evaluate treatment response on the degree of impairment (MMSE-K 21?23 and 24?26). LGNC-07 led to improvements in memory by marginally increasing delayed recognition in the Rey?Kim memory test (P?=?.0572). Stratified analyses showed that LGNC-07 improved memory and selective attention by significantly increasing the Rey?Kim memory quotient and word reading in the subjects with MMSE-K scores of 21?23 (LGNC-07, n?=?11; placebo, n?=?9). Electroencephalograms were recorded in 24 randomly selected subjects hourly for 3 hours in eye-open, eye-closed, and reading states after a single dose of LGNC-07 (LGNC-07, n?=?12; placebo, n?=?12). Brain theta waves, an indicator of cognitive alertness, were increased significantly in the temporal, frontal, parietal, and occipital areas after 3 hours in the eye-open and reading states. Therefore, this study suggests that LGNC-07 has potential as an intervention for cognitive improvement.
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KEYWORD
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attention, electroencephalography, green tea, memory, neuropsychological test, l-theanine
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